Using the PICAXE-14M2 microcontroller is a breeze. First, connect it to your computer using a simple serial connection. Then, you can start programming it in the free BASIC development environment. When programming, take your time to understand the basic commands and functions. As for maintenance, keep it in a dry and clean place, away from moisture and dust. If you encounter any problems, refer to the datasheet or the 'What is PICAXE' document. Remember, this chip is a great starting point for beginners, so don't be afraid to experiment and learn!